Month: August 2019

Scientists solve mystery of the eye

first_img How the drug isotretinoin zaps acne ( — Scientists have a good overall understanding of human vision: when light enters our eyes, it is focused by the lens and strikes the retina in the back of the eye. The light causes some of the millions of photoreceptor cells that line the retina to undergo a chemical change, which send a message through the optic nerve fiber to the brain, which creates a picture. However, there are still a few unresolved questions in the details of the vision process, one of which is why the eye evolved to use a certain light-absorbing chromophore called 11-cis-retinal instead of one of its isomers (i.e., molecules with the same atoms but in different arrangements), such as 7-cis, 9-cis, or 13-cis. More information: Sivakumar Sekharan and Keiji Morokuma. “Why 11-cis-Retinal? Why Not 7-cis-, 9-cis-, or 13-cis-Retinal in the Eye?” Journal of the American Chemical Society. DOI:10.1021/ja208789h A schematic representation of 7-cis- (PSB7, green), 9-cis- (PSB9, blue), 11-cis- (PSB11, black), 13-cis- (PSB13, purple), and all-trans-retinal (PSBT, red). PSB stands for “protonated Schiff base,” the linkage between the retinal chromophore and the opsin protein. Image credit: Sekharan and Morokuma. ©2011 American Chemical Society Journal information: Journal of the American Chemical Society Chemists Sivakumar Sekharan from Emory University in Atlanta, Georgia, and Keiji Morokuma from Emory University and Kyoto University in Kyoto, Japan, describe the eye’s use of 11-cis-retinal as “one of the basic and unresolved puzzles in the chemistry of vision.” But by taking advantage of the rapid advances in hybrid quantum mechanics/molecular mechanics (QM/MM) computational modeling, the researchers have found that the answer to this puzzle lies in electrostatic interactions in the retina. Their study is published in a recent issue of the Journal of the American Chemical Society.The retina contains light-sensitive photoreceptor cells known as rods and cones, which convert incoming light into electrical impulses that are sent to the brain. On the top of every rod and cone is a region that contains opsin proteins bound to 11-cis-retinal chromophores, which together are called rhodopsin. When light strikes the retina, the 11-cis-retinal chromophores absorb the light, which causes them to undergo an isomerization and change their molecular configuration from 11-cis-retinal to all-trans-retinal in a matter of picoseconds. The difference between these two isomers involves the positions of the hydrogen atoms, a shape change that causes the opsin protein to change shape in response. The opsin shape change, in turn, leads to a cascade of biochemical reactions in the photoreceptor cell that ultimately generate an electrical impulse.Since the 11-cis-retinal is the retina’s first responder to incoming light, its unique geometric configuration clearly plays an important role in the vision process. However, theoretically there are a handful of other retinal isomers that seem capable of performing this task, yet for some reason photoreceptor cells only function with 11-cis-retinal (and the corresponding 11-cis-rhodopsin). Explore further Citation: Scientists solve mystery of the eye (2011, November 17) retrieved 18 August 2019 from Copyright 2011 All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of “Because the primary event in vision involves no breaking of chemical bonds but only a conformational change in the shape of the molecule from bent cis to the distorted all-trans form, scientists wondered why 7-cis-, 9-cis- or 13-cis- isomers could not achieve this goal,” Sekharan told answer this question, the researchers built computational models of the rhodopsin found in the eyes of cows, monkeys, and squids. While all known animals’ eyes use 11-cis-retinal, the opsin in different animals contains different numbers and positions of amino acids. Using a cutting-edge QM/MM modeling method called ONIOM (Our own N-layered Integrated Molecular Orbital), the researchers prepared models that matched different animals’ opsins with 7-cis, 9-cis, 11-cis, and 13-cis molecules serving as chromophores. In these artificial rhodopsins, the researchers analyzed the structure, stability, energetics, and spectroscopy to try to find out what makes 11-cis-retinal nature’s preferred isomer.The results of the modeling showed that differences in the electrostatic interactions between the opsin protein and the retinal chromophore played the biggest factor in the natural selection of 11-cis-retinal over the other cis isomers. Due to electric charges, the link between 11-cis-retinal and opsin has a higher stability than the links between other cis isomers and opsin, making it the most favorable choice. “Our results show that the strong electrostatic interaction between retinal and opsin favors the natural selection of 11-cis- over other cis-isomers and arguably prepares the chromophore for the upcoming photochemical event,” Sekharan said. “This indeed is very surprising given the fact that, outside the protein environment, 11-cis-retinal is one of the least stable isomers. Apparently, our results on cow, monkey and squid demonstrate that organisms everywhere may tend to gravitate towards common selection.”Sekharan added that the results not only provide a better understanding of the eyes on a molecular level, but could also have applications for artificial retinas.“Because rhodopsin serves as a decisive crossing point between an organism and its environment, we have been always impressed with this interesting interface by seeing it, say, from the outside and not from the inside,” he said. “Using the ONIOM-QM/MM method we developed, we can ‘enter’ deep into the dark side of this fascinating molecule. One of interesting findings to emerge out of our investigation is that 9-cis-retinal is only slightly higher in energy compared to 11-cis-retinal. This provides strong evidence for the presence of 9-cis-rhodopsin in nature, which in turn may well aid in optimizing the parameters required for designing artificial retinas.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Study offers hint at a way to predict blow up fires

first_img Play Structure-to-unstructured transition followed by an unstructured-to-structured transition (1/10 actual speed). A 1-cm triangular bump, positioned 13 cm away from the ignition end of a 2.54-cm-wide strip (small mesh) triggers the first transition (structured-to-unstructured). A second bump, positioned 5 cm away from the first (and 8 cm away from the end of the strip), triggers the second transition (unstructured-to-structured). Credit: PNAS, doi: 10.1073/pnas.1417043112 The research pair acknowledge that real world fires, whether in buildings or forests are far more complex with many more variables at play, but believe what they have found likely has enough in common with real fires to warrant further research—which could lead to offering firefighters a way to better predict when a fire is suddenly going to change. Play Failed structured-to-unstructured transition on a double-layer strip (1/10 actual speed). A flame propagating along a stack of two 2.54-cm-wide strips (large mesh) containing a 1-cm triangular bump. Credit: PNAS, doi: 10.1073/pnas.1417043112 Journal information: Proceedings of the National Academy of Sciences © 2015 Citation: Study offers hint at a way to predict ‘blow up’ fires (2015, February 10) retrieved 18 August 2019 from (—A pair of researchers with Harvard University has found that a simple experiment they conducted in their lab might lead to helping predict when fires in buildings or forests might be on the verge of becoming “blow up” fires. In their paper published in Proceedings of the National Academy of Sciences, Jerome Fox and George Whitesides describe their experiment and why they believe what they have learned might help firefighters at some point in the future. More information: Warning signals for eruptive events in spreading fires, Jerome M. Fox, PNAS, DOI: 10.1073/pnas.1417043112AbstractSpreading fires are noisy (and potentially chaotic) systems in which transitions in dynamics are notoriously difficult to predict. As flames move through spatially heterogeneous environments, sudden shifts in temperature, wind, or topography can generate combustion instabilities, or trigger self-stabilizing feedback loops, that dramatically amplify the intensities and rates with which fires propagate. Such transitions are rarely captured by predictive models of fire behavior and, thus, complicate efforts in fire suppression. This paper describes a simple, remarkably instructive physical model for examining the eruption of small flames into intense, rapidly moving flames stabilized by feedback between wind and fire (i.e., “wind–fire coupling”—a mechanism of feedback particularly relevant to forest fires), and it presents evidence that characteristic patterns in the dynamics of spreading flames indicate when such transitions are likely to occur. In this model system, flames propagate along strips of nitrocellulose with one of two possible modes of propagation: a slow, structured mode, and a fast, unstructured mode sustained by wind–fire coupling. Experimental examination of patterns in dynamics that emerge near bifurcation points suggests that symptoms of critical slowing down (i.e., the slowed recovery of the system from perturbations as it approaches tipping points) warn of impending transitions to the unstructured mode. Findings suggest that slowing responses of spreading flames to sudden changes in environment (e.g., wind, terrain, temperature) may anticipate the onset of intense, feedback-stabilized modes of propagation (e.g., “blowup fires” in forests). Fire season in West expected to get more intense This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. All firefighters are familiar with the term “blow up” fire—it is when a fire suddenly grows in magnitude and intensity creating a very dangerous situation. Unfortunately, there is no way to predict when a blow up is likely to occur, thus those attempting to put out such fires are usually surprised when it occurs. In this new effort, the research pair thought that the behavior of blow up fires showed similarities to phase transitions in other instances and devised a simple experiment to see if they could confirm their suspicions.In the lab, the researchers placed nitrocellulose strips on a wire mesh grid (a piece of window screen) and filmed what occurred when they lit one end of the strip. The strips burn, like a fuse, from one end to the other, and if left alone, generally do so in a slow orderly fashion. But, in the lab, the researchers found that they could cause a blow up by changing the conditions under which the strip was burned, by altering the slope, for example, adding wind, or by introducing a bump by bending the strip prior to lighting. By fine tuning the alterations, they were able to nudge the fire ever closer to a blow up which allowed them to confirm that the blow ups conformed to what is known as “critical slowing down”—where the closer a system is to collapse, the more time it takes to recover from an event. PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen Explore furtherlast_img read more

After bypoll drubbing BJP not too upbeat on prospects

first_imgThe civic polls, including in Kolkata, will be followed by elections to 92 other civic bodies across the state on April 25. The party said it will be concentrating more on the 2016 Assembly polls.Trinamool Congress had retained both Bongaon Lok Sabha and Krishnaganj Assembly seats with huge margins in the by-polls held in the month of February. Though the BJP is banking on the excuse that the civic polls will be a state show (with a fact that it will organized by the State Election Commission and managed by local administration), ground realties suggest that the saffron party’s base in the state is in shambles, with its support base declining.Speaking to the Millennium Post, BJP national secretary and in charge of West Bengal, Siddharth Nath Singh said: “The civic election will be highly rigged as it is controlled by the state administration. We recently had a meeting with the state leadership in Delhi and our main focus is to concentrate on 2016 Assembly poll.”On the context of whether the party is happy with the functioning of West Bengal unit of the party with amid rumours like BJP president Rahul Sinha might be removed with party MP Babul Supriya, he said: “We are extremely happy with Sinha and there is no question of removing him.”However, sources said that there is infighting between the state BJP and the central leadership and it has a taken a serious turn in the recent past. It was learnt that BJP president Amit Shah had a detailed meeting with the state leadership and reportedly expressed unhappiness over the party’s West Bengal leaders failing to take advantage of the political situation that was created in favour of the party after the Lok Sabha polls.last_img read more

Dos and donts for running a marathon

first_imgRunning a marathon is never easy but with the right training and following the dos and don’ts, one can not only avoid serious injuries but also enjoy the run, says an expert.Before the run:* Ensure that a part of your longest run (full marathon – 32 to 38 km, half marathon – 21 to 24 km) has about 60-70 per cent distance being run at your goal/race pace. For example, if you intend to finish the half marathon in one hour 59 minutes, the goal pace is 5:40 per km. Also Read – Add new books to your shelf* Also, you need to get familiar with the running course so that you don’t get bothered with unexpected inclines. Practice your long runs with some inclines added so you know how much to slow down on such inclines on the day of the run.* A day before the marathon, it is recommended to stay off one’s feet, and drink a lot of fluids to stay well hydrated.* One also needs to ensure that you don’t skip food, nor go on any kind of diet just before the race. Taking meals that are high (65-75 per cent) in carbohydrates is recommended. There should also be adequate protein intake. Also Read – Over 2 hours screen time daily will make your kids impulsive* Lastly, mentally preparing for your race by visualising the course and your race plan is an integral part of the final preparation. A night before the big run, lay out your gear, have an early dinner and go to bed early.* On the big day, it is critical to take an easily digestible meal two hours prior to the race start time. Additionally, drinking adequate water to digest this meal is also important.On the start line and during the run:* Just before one starts running for the big race, it is important to do a light warm up. Also, sipping water every now and then until the start, is recommended. * For the first half of your race in a half marathon, do not run faster than your goal pace as it might lead to cramps. If the sun isn’t being too nice, use a sponge to cool your head and back of the neck. Also, it is vital that one keeps sipping on water in order to avoid dehydration because once this sets in it becomes difficult for one to keep up to the goal pace.After the run:* On finishing the race no matter how tempted one is to sit down on the grass and stretch the muscles, don’t. This is because the muscles are inflamed and to ensure that one recovers fast, they need to move around to facilitate smooth blood circulation.* Having a meal which comprises of carbohydrates and proteins as early as possible will replenish ones glycogen levels. The proteins will help in repairing the damaged tissue.* For quick post marathon recovery, getting a good night’s sleep, drinking lots of fluids throughout the day and eating food which is high in proteins and carbohydrates is the key to repair and refuel yourselves.* Stretching and ice baths are other ways to boost one’s running recovery. This will help in increasing blood flow to the muscles while an ice bath will help in reducing post marathon soreness by reducing inflammation.last_img read more

Photo fest on sustainable development kicksoff

first_imgThe second edition of ‘Habitat Photosphere’, a year-long photography festival conceptualised and curated by Dr Alka Pande and initiated by India Habitat Centre, New Delhi, has finally kicked off. The event – which revolves around the theme of sustainable development, commenced with the announcement of this edition’s four awardees of the Photosphere fellowship. Selected through an open call for application process, the four photographers – Juhi Saklani (New Delhi), Thulasi Kakkat (Kochi), Zishaan Akhbar Latif (Mumbai) and Syed Adnan Ahmed (Rajasthan) – have been given a Rs 2 lakh grant to produce a significant body of work that will be exhibited during the grand finale of the festival, slated for February – March, 2019. The awardees will be mentored throughout the year by an eminent panel of photographers including Aditya Arya, Bandeep Singh, Parthiv Shah and Prabir Purkayastha. Also Read – Add new books to your shelfHabitat Photosphere will bring together the spheres of photography and sustainability, through fellowship and mentorship, followed by a month-long grand finale of exhibitions, workshops, talks and screenings at India Habitat Centre. In addition, there will also be curated events and exhibitions on the theme of sustainability. The festival is followed up with a photo-book titled ‘Visual Arts Journal 2018 Photography: Art, Archive, Document’ that aims to position itself as a handbook of diverse scholarly works on photography from prominent authors, curators, and art practitioners. Also Read – Over 2 hours screen time daily will make your kids impulsiveDr. Alka Pande, Festival Director, Habitat Photosphere stated: “We are a festival with a green conscience. While the first edition dealt with the subject of Panchtattvas (five elements) under the meta-narrative of sustainable development, this year’s focus will be on cultural sustainability, which is as relevant and pertinent as ecology and environment, and in fact, impact it as well. Also this year, there was a shortlist round where eight candidates were first shortlisted, and from which the final four were then selected.” Delhi-based Juhi Saklani’s photographs will be of trees and roots that grow out of the old walls and buildings, out of unexpected spaces. The idea is to emphasise the synergy and interconnectedness of life. The performative silhouette of the artist placed amongst these surroundings explores this interconnection. Thulasi Kakkat focuses on the eco-cultural significance of Theyyam, a ritualistic form of worship from Kerala. An unmistakable umbilical link existed between Theyyam, with its organic accouterments drawn from nature, and the biodiversity-rich wilderness of the sacred groves (Kaavus) home to Malabar’s pantheistic deities. A government report published in 1956 had identified some 10,000 Kaavus in various parts of Kerala. Fifty years hence, in 2015, just about 1,200 of them survived. Development has ushered most Theyyams out of what remained of the groves to built structures with open spaces engirdled by high compound walls.Speaking about the work, Kakkat said: “My aim is to document the surviving Kaavus with their integral Theyyam deities. I seek to explore the strong underpinning of eco-feminism that remains embedded in Theyyam, with its subaltern ecological identity that is at war with its own opportunistic transformation.”Syed Adnan Ahmed is dealing with the culturally and socially sensitive subject of rooster combat where animals are pitted against each other resulting in fatal injuries and pain.Zishaan Akhbar Latif is developing work around the “withering” away of the river Majuli in Assam, with an aim to speak to about larger consequence of climate change and those who continue to deny its ​existence. The primary sponsor for Habitat Photosphere 2018-19 is Dalmia Bharat.last_img read more

Campaigning ends with CMs roadshow

first_imgKolkata: Trinamool Congress supremo Mamata Banerjee’s three roadshows on Kolkata’s streets on the last day of campaign for the final phase of the ongoing Lok Sabha elections, just hours before the Election Commission’s campaign ban kicks in at 10 pm, witnessed tremendous response from her party workers and the common people alike.Hundreds lined up on both the sides of the streets as the first roadshow hit Diamond Harbour (DH) Road on a hot Thursday afternoon after it kick-started from Thakurpukur 3A bus stand. People tried to get a closer look at the charismatic leader giving her security personnel and police a tough time. Roadshows were conducted in favour of Mala Roy and Mimi Chakraborty contesting with Trinamool Congress’ tickets from South Kolkata and Jadavpur respectively. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataThe rally grew bigger in size as it marched down DH Road with the joining of thousands of Trinamool Congress supporters. People started congregating as the news of Banerjee taking part in roadshows reached the local residents of Thakurpukur, Behala, Taratala areas and to those living on either side of DH Road. Braving the heat, the roadshow witnessed a sea of people while passing through Behala. Many were found queuing up on both sides of the road while some of whom tried to capture the moment on their mobile cameras. People waved at Banerjee when she passed Behala Chowrasta area and shouted slogans in her support. Banerjee did not disappoint them and reciprocated by waving back at them. People gathered with TMC’s festoons and flags across the entire stretch. The first roadshow concluded at Taratala. Also Read – Lightning kills 8, injures 16 in stateThe second rally began at Sukanta Setu in the evening and ended at Gariahat. It went past all the important locations of South Kolkata. In some areas, women were found blowing conch shells to hail Banerjee who has emerged as the key challenger to Modi and the saffron party and will play a major role in forming the next government at the Centre. As the roadshows touched down the streets, TMC activists and leaders shouted political slogans to oust the Narendra Modi government from the Centre. The slogans resonated in the air as the roadshows crossed various lanes and bylanes of the city. People who came for shopping in Gariahat witnessed the mammoth rally. The third roadshow kicked off at Ballygunj Phari and ended at Harish Chatterjee Street, near her residence, later in the evening. Support for Mamata remains unwavering with the masses chanting anti-BJP slogans as she made her was along the areas for her rallies. Concerns over national issues remain foremost on the voters’ minds, who gathered in hundreds for the final chapter of the campaign before the state goes to polls in the final phase of the Lok Sabha elections on May 19.last_img read more

Monitoring cell advisor visits Raina Jamalpur to interact with beneficiaries

first_imgKolkata: Colonel Diptangshu Chowdhury, advisor of the monitoring Cell constituted by Chief Minister Mamata Banerjee to take stock of various government schemes, visited Raina and Jamalpur to interact with the beneficiaries and to listen to their complaints.Colonel Chowdhury took a detailed stock of the social schemes run by the Mamata Banerjee government. He examined various aspects as to how the schemes were being implemented in the district. This is for the first time in the history of the state that a representative deployed by the Chief Minister is visiting the districts to ensure that beneficiaries in the remote areas can reap the benefit of various government schemes. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataIt has been a huge success for the monitoring cell as Bankura District Magistrate Umashankar S attended a public interaction program in the name of Sahamarmi Sabha in a remote village of Taldangra Block in Bankura to address a grievance redressal and to perform a social audit on schemes and beneficiaries. The villagers also took active part in the event. The Chief Minister has given a platform where the beneficiaries of various government schemes can directly converse with the Chief Minister’s office, sharing their feedback and suggestions for the improvement of the delivery mechanism. Also Read – Lightning kills 8, injures 16 in stateOnce a beneficiary from the districts raises his/her issue with the Chief Minister’s office through email at, it will be thoroughly examined and replied to within 10 days. One of the main objectives of the initiative is to bridge the gap between the beneficiaries and the government, thereby ensuring a smooth implementation of all the schemes. The focus of the move is to reach out to the marginalised beneficiaries in particular. The monitoring cell has already addressed many other issues. The grievances of two widows at Purulia’s Bagmundi have been addressed within two days.last_img read more

VIDEO Ezekiel Elliott in hot water after exposing womans breasts at St

first_imgCowboys rookie running back Ezekiel Elliott is in more hot water off the field after pulling down a woman’s shirt and exposing  her breasts while carousing at a St. Patrick’s Day Party.It will be interesting to see if the video catches the attention of Roger Goodell and the NFL league office. The league still has an open investigation regarding a domestic violence allegation from a former girlfriend.Elliott and the woman in the video reportedly continued to party it up after he exposed here shirt. It still doesn’t excuse his behavior.Check out the video:last_img

VIDEO High school junior LaMelo Ball announced the release of his own

first_img Advertisement After a month or so break from the Ball family, this week they have stormed back into the spotlight with the trailer for a new family reality show, and today, the youngest Ball, high school junior LaMelo, announced the release of his own Big Baller Brand shoe.It’s called the Melo Ball 1, and the commercial announcing the release features Ball babbling, shooting hoops, eating cherries and driving in a Lambo. Lonzo makes a brief appearance. It’s a steal at $395. You can’t afford not to do it.It’s unclear if this brand endorsement might impact Ball’s eligibility to play college basketball at UCLA, where he has already committed. Stay tuned.? EXCLUSIVE: LaMelo Ball becomes the first high school player to have his own sneaker.Introducing the MB1 by BBB:— SLAM Magazine (@SLAMonline) August 31, 2017last_img read more

The NBA is blowing it by not televising the AllStar draft

first_imgWhy would anyone want the Jags in the Super Bowl over the Patriots?Everyone claims to love the underdog, but every time a true Cinderella team makes a deep run in the NCAA Tournament, the viewership numbers always nosedive. Even though people claim to be sick of watching powerhouse schools like Duke, they always watch.In this year’s NFL Playoffs, the Jacksonville Jaguars are everybody’s favorite underdog after taking down the Steelers at home, and in the echo chamber of social media, many are hoping for the fairytale run to continue with a win over the evil empire Patriots. Colin disagrees, and can’t understand why anyone would want to see Blake Bortles over the greatness of Tom Brady in the Super Bowl.Guests: Alvin Kamara – Saints running back and co-offensive rookie of the year is in-studio discussing his breakout rookie year; when he knew he was a good fit in the offense; and what he told Marcus Williams after Stefon Diggs’ game-winner.Doug Gottlieb – FS1 Analyst and host of The Doug Gottlieb Show is in-studio is to explain why no one really wants the Jags in the Super Bowl;Bucky Brooks – NFL Network Analyst is in-studio talking NFL Conference Championships; and if Case Keenum is the long-term answer for the Vikings. The NBA is blowing it by not televising the All-Star draftThe NBA is changing up the All-Star selection process this year by allowing two captains (Steph Curry and LeBron James) pick their teams by choosing available all-stars. The draft is intriguing to many fans, and Colin thinks the NBA – which is the best major sports league in terms of creating stoylines – is making a huge mistake by not televising the draft.The league is trying to avoid the potentially awkward situation of publicly damaging some of the fragile egos when one player is inevitably picked over another, or last, but Colin believes that’s why it would be must see TV for fans. The NBA usually gets it right, but they botched this layup.last_img read more

Colin Trusted source says LeBron to the Lakers is very much in

first_imgColin was giddy about the possibility of LeBron jumping ship from the Cavs to L.A. in 2018 free agency, but then he saw the Lakers play this season, and the circus created by LaVar Ball, and concluded there was no chance of it happening.Even though Colin proclaimed #LeBronzo was dead, a call he received from a trusted, well-connected source as he boarded a plane that has made him reconsider. The source told him that LeBron to L.A. is very much alive, and a large contingent of his business team is already making the move to the West Coast.Watch Colin explain why he’s back on LeBronzo:“I got a call Thursday as I was about to board a plane…LeBron and the Lakers is very much in play.” — @ColinCowherd— Herd w/Colin Cowherd (@TheHerd) January 29, 2018 Advertisementlast_img read more

7 Steps to a Healthy PC

first_img How Success Happens Hear from Polar Explorers, ultra marathoners, authors, artists and a range of other unique personalities to better understand the traits that make excellence possible. 4 min read Listen Now Your computer is probably the single most important piece of equipment in your business. When it’s not working properly, your entire business slows, employee productivity dips, customers aren’t served–or aren’t served properly–and partners get frustrated. If you’re ignoring your computer’s maintenance and upkeep, you could find yourself in trouble someday.The good news is, maintaining your computer’s health doesn’t have to involve much time or many resources. Here are seven things to consider that will help you take better care of your computer:1. Think before you install. So many times I’m told that someone’s computer isn’t working properly only to discover they’ve downloaded several programs from the internet or from a CD of a friend. Installing software on your computer will take up space on your hard drive, which will eventually slow your computer down. These random programs could also be an open door for viruses and cause other programs to crash. So install as few programs as possible on your computer. If you can, use a second computer to “play with” and test programs you’re thinking of using company-wide.2. Install the right software. Ensuring your computer is protected from digital vandals is critical if you want to keep information safe. It’s therefore important that you install both an antivirus program and a firewall software program. These two critical pieces of software, which you should update on a regular basis, will serve as a wall of protection for your computer.3. Update your operating system. Microsoft Windows is the software you’re most likely using to power your computer programs and control how your computer operates. It’s critical that you update Microsoft Windows on a regular basis by going to the “Windows Update” website http://www.windowsupdate.comto automatically update your operating system.4. Dump what you don’t need. Every few months you should regularly inventory your computer to find and delete the programs you don’t really need. These unused or unnecessary programs take up valuable hard drive space, and if you’re not using them, you should remove them from your computer via the “Add/Remove” programs option in your control panel.5. Defragment your hard drive. Your hard drive is one of the hardest-working parts of your computer-you’re using it all the time, every day (whether you realize it or not) to access the programs you use and store the files you create. But the hard drive doesn’t save the files in any particular order; instead, it uses the first empty space it encounters (space that’s created when you delete files). So the pieces of data become scattered around the hard drive, making it slower for you to access the data stored there. That’s why it’s critical to defrag your hard drive on a regular basis to keep things running as quickly as possible. Do it monthly if you’re a “light” computer user and weekly if you’re a power user.6. Keep things clean. I’ve seen offices where people have paper and stickies all over their computers, covering up the air vents. To help ensure your computer runs smoothly, don’t cover the air vents-you need to keep the internal components as cool as possible. You should also vacuum your computer every few months to clean out the dust that accumulates.7. Security is important. When things do go wrong, you want to be prepared. Therefore, its important to always backup your important data. You can back it up online, to an external hard drive or to a central server, or you can place the data on CD-ROMs or DVDs. Whatever method you choose, make sure to back it up on a regular basis so that if your computer crashes, you can easily recover your important data.Ramon Ray is’s “Tech Basics” columnist and editor of He’s the author ofTechnology Solutions for Growing Businesses and currently serves on the board of directors and the technology committee for the Manhattan Chamber of Commerce. Opinions expressed by Entrepreneur contributors are their own. November 17, 2006last_img read more

How can I implement new technology into my business

first_img There are a number of technologies that can help you with various aspects of the business. If you don’t have one already, you should look into a good accounting package designed specifically for small businesses (rather than personal accounting software). They’re fairly easy to use and will help you keep track of your cash flow and make things easier when tax time rolls around.You’ll also want some sort of customer relationship management (CRM) system. Being able to capture information about customers — especially their preferences and quirks — really helps with building repeat business. It can also help you see who your best customers are so you can market to them more effectively. You can either purchase software to run it yourself, or you can use a “hosted” model where you login on the Internet to use it but the supplier takes care of all the technical management.You don’t say how you manage incoming orders, but if you don’t have a Web-based system for placing orders you’ll want to look into one. These days people are used to ordering just about everything online. If you can give them that option you’ll increase the convenience. Be sure the software you use allows them to schedule pickups in advance. You’ll also want to include a “live call” button on the site so customers can easily reach you by phone if they’re having problems with the online system or have questions.On the marketing and branding side, one thing you can do is invest in an application that allows you to create very versatile email campaigns without a great deal of effort. With these packages you can design and schedule campaigns, build opt-in lists (mailing lists where the recipient has already said he/she would like to receive the email), create simple email announcements and newsletters, and track results to help you refine your next campaign. Using a hosted system helps keep your costs down over purchasing and installing the software on your own servers and removes the burden of maintaining the software and hardware. April 9, 2009 min read Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Opinions expressed by Entrepreneur contributors are their own. Register Now »last_img read more

Malwarebytes 32 promises better memory usage and stability

first_imgMalwarebytes 3.2 promises better memory usage and stability by Martin Brinkmann on July 31, 2017 in Software – Last Update: September 16, 2017 – 39 commentsMalwarebytes, maker of the security product of the same name, have released Malwarebytes 3.2 Beta which promises better memory usage and other improvements.The company has been fighting will all sorts of issues after the release of Malwarebytes 3.0 and the merging of all company products into a single application.Core issues that users of the new application version experienced were high memory usage, stability issues, and issues with functionality. The latter especially with components that would turn themselves off automatically, or would not turn on at all in first place.Updates to the program have improved the situation, but it is still far from ideal. The issue with components seems to have been fixed for instance, judging from my own experience with the software and user comments on recent updates to the program. Memory usage is still pretty high however, especially when compared to the latest 2.x versions of the security software.Malwarebytes 3.2Memory usage has been improved further in Malwarebytes 3.2. The main process, MBAMSrvice.exe drops below the 200,000 K mark on 64-bit versions of Windows. While that is good, I still consider Malwarebytes to be a fairly heavy program especially since it runs three processes on Windows machines.The developers of the software have fixed several stability related issues in the new version as well. This includes crashes and hangs related to the service and tray application, but also the user interface.Malwarebytes added an option to the application to download and install beta versions of the application automatically. Users interested in those had to download the updates manually up until now to install them on devices running the software.It is usually not a good idea to install beta software on production systems, but if you want cutting edge and don’t mind running into bugs every now and then, this may be an option. Also, useful to test new versions of the security software early before deploying them on production systems or on a wider scale.You find the new option under Settings > Application > Beta Application Updates.The “install application updates” button in the program interface will download and install new components now regardless of limits that may be in place in regards to automatic updates.You find additional information on the changes and the download link for the new Malwarebytes 3.2 Beta update on the official company forum.Now You: Which security software do you run primarily?SummaryArticle NameMalwarebytes 3.2 promises better memory usage and stabilityDescriptionMalwarebytes, maker of the security product of the same name, have released Malwarebytes 3.2 Beta which promises better memory usage and other improvements.Author Martin BrinkmannPublisher Ghacks Technology NewsLogo Advertisementlast_img read more

Integrate Chrome and Firefox browsing with Windows Timeline

first_imgIntegrate Chrome and Firefox browsing with Windows Timeline by Martin Brinkmann on July 16, 2018 in Firefox, Google Chrome – Last Update: July 16, 2018 – 6 commentsWindows Timeline Support is a free browser extension for Chrome-based and Firefox-based web browsers that integrates the browsing history with Windows 10’s Timeline feature.Microsoft introduced Timeline in Windows 10 version 1803 as a way for users to better keep track of activity on the system. Timeline was limited to some native apps like Microsoft Edge, News, Microsoft Office and some other built-in applications, and the situation has not really improved that much since the introduction.So, to activate Timeline you simply use Winodws-Tab to display its interface. Timeline displays activity chronologically and you can click on items to open websites again, load documents, or go back to where you were on that particular day.Windows 10 users who don’t use Microsoft Edge for web browsing — and not many do — may have noticed that Timeline does not work with any third-party web browser. While that is not a problem if you don’t use the feature, it may be if you do.Windows Timeline SupportWindows Timeline Support for Chrome and Firefox, and compatible browsers like Vivaldi, changes that by integrating the browsing history of compatible browsers with Timeline on Windows 10.You do need Windows 10 version 1803 or later for this and the extension. Note that it is not enough to just install the extension and be done with it; it requires that you sign in to your Microsoft Account to sync the browsing data with the account and thus Windows 10.The browsing history is published as activities to the Microsoft Graph by the extension as the author explains on the project’s GitHub website.Windows Timeline Support is a web extension that integrates Windows Timeline support into popular browsers. This is done by publishing your browsing history as activities to the Microsoft Graph (so a Microsoft Account is required to use this extension). Personal Microsoft Accounts are confirmed to work, work and school accounts should work.The very first thing you need to do therefore is to sign in to the Microsoft Account. Just click on the extension icon in the browser’s interface and click on the sign in option. Follow the instructions to sign in and sync the browsing history with the selected account.The extension won’t sync Incognito Mode or Private Browsing Mode data with the account. Users can open the Microsoft Activity History Dashboard at any time to delete and manage the data.The extension is open source which means that you can check out the source code before you install it.One interesting feature of Windows Timeline Support is that you can continue your browsing on other devices if you sign in to the same Microsoft Account. You can push the current tab to any device linked using the browser extension.Closing WordsYou may find Windows Timeline Support useful if you do use Windows Timeline and Chrome, Firefox, or another third-party browser that the extension is compatible with.Now You: do you use Timeline or would use it if it would be available on your devices?Summary12345 Author Rating4.5 based on 2 votes Software Name Windows Timeline SupportSoftware Category BrowserLanding Page Advertisementlast_img read more

Bitdefender Antivirus Free vs Antivirus Plus

first_imgBitdefender Antivirus Free vs. Antivirus Plus by Martin Brinkmann on July 24, 2018 in Security – Last Update: July 28, 2018 – 61 commentsBitdefender is a highly respected security company that refreshes its lineup of security solutions each year (just like any other antivirus company out there).Company products are usually top of the class when put to the test by independent test institutes such as AV Test or AV Comparatives.Home users who run Windows have the choice between four different Bitdefender products of which only one, Bitdefender Antivirus Free Edition, is free.Bitdefender launched a free antivirus solution years ago but does not advertise it as much on the company website as the paid products.It is difficult to find out how Bitdefender products differ from one another. The following overview provides you with the information so that you can better pick the most suitable product.I focus the comparison on the two antivirus products but will compare those two with Bitdefender Total Security, the company’s top of the line product.Bitdefender Antivirus Free vs. Antivirus PlusThe comparison looks at the 2019 lineup right now which Bitdefender released recently. We will update the overview when next year’s refreshes are released.The pricingBitdefender Antivirus Free Edition is available for free.Bitdefender Antivirus Plus 2019 is available for $59.99 but you find discounts for the product usually.Bitdefender Total Security 2019 is available for $89.99.Compatibility and installationBitdefender Antivirus products are compatible with Windows 7, Windows 8.1, and Windows 10 operating systems. They require systems with at least 1.5 Gigabytes of RAM and 800 Megabytes of hard disk space (recommended 2 Gigabytes), and an Intel Core Duo 2 GHz processor or better. Software-wise, Internet Explorer or higher is required.The online installer requires an Internet connection. It will download approximately 360 Megabytes of data to the local system if you install Bitdefender Antivirus Free Edition or approximately 450 Megabytes if you download Bitdefender Antivirus Plus.Both installers reveal that anonymous usage reports (free edition) or product reports (plus edition) are sent to Bitdefender. You may uncheck the option in both products to block the sending of the data to Bitdefender.The installer tries to install a root certificate and requests that all open browsers are closed to do so.Feature comparisonFeatureFree AntivirusAntivirus PlusAdvanced Threat DefenseyesyesRansomware ProtectionnoyesWeb Attack ProtectionyesyesAnti-PhishingyesyesWi-Fi Security AdvisornoyesOnline Banking ProtectionnoyesVPNnoyesPassword ManagernoyesSearch AdvisornoyesVulnerability ScannoyesFile ShreddernoyesFree Online SupportnoyesBitdefender Antivirus Free Edition offers protection against common threats; it features an antivirus module and protects the system against ransomware attacks, phishing, and web attacks.The paid version supports the following additional features:Access to a VPN with 200 Megabytes of daily traffic included.Password Manager to save passwords, credit card data, and other data securely.Safe Files to protect important files from tampering.Search Advisor which checks URLs displayed in search results.Vulnerability Scan to scan the system for security issues and vulnerabilities.Ransomware ProtectionOnline Banking Protection using a secure environment that Bitdefender calls Safepay.Wi-Fi Security Advisor recommends to use the SafePay browser when you connect to public wireless networks.File Shredder deletes files so that they can’t be recovered anymore.Both antivirus products lack features that Bitdefender reserves for its Internet Security and Total Security products. They are:Webcam protection to prevent unauthorized access to a device’s cam.Firewall to control network traffic.Parental Control to protect minors.File Encryption to store sensitive files in encrypted containers.Anti-Theft to run anti-theft tools.Speed Up tool to improve performance.Closing WordsWhether Bitdefender Antivirus Free Edition is sufficient for your needs depends on a number of factors. Do you need the extra functionality that Antivirus Plus or the more expensive Bitdefender products offer?The free version covers the most important bases with the exception of a firewall which it and Antivirus Plus don’t offer.Now You: Which security software do you use?SummaryArticle NameBitdefender Antivirus Free vs. Antivirus PlusDescriptionFind out which Bitdefender product is right for you; is Bitdefender Antivirus Free Edition sufficient or should you pick one of the paid products instead?Author Martin BrinkmannPublisher Ghacks Technology NewsLogo Advertisementlast_img read more

Over 500 Critically Endangered Vultures Die From Eating Elephants Poisoned By Poachers

first_img Search All Bestseller DEAL OF THE DAY Wow facts 4Share this videoCopyPausePlay00:00% Buffered0PreviousPausePlayNextLive00:00 / 00:00UnmuteMuteExit fullscreenFullscreenCopy video urlPlay / PauseMute / UnmuteReport a problemLanguageBackMox PlayerDefaultEnglishEspañolУкраїнськаРусскийVultures Vs PoachersThis is not the first time that vultures died because of poachers. In 2003, over 500 birds, including vultures, also died in Namibia after eating the carcasses of elephants that were poisoned. Evidently, creatures such as vultures are rather problematic for poachers because they tend to give away the locations of poachers’ activities when they flock to the site of the carcass. Unfortunately, this leaves the creatures quite vulnerable to poisoning.Because of the incident, authorities are now working to decontaminate the area from the poison to avoid further deaths. They are also encouraging members of the public to report any suspicious activity that may be suggestive of environmental poisoning.White-Backed VulturesOf the vulture deaths, white-backed vultures suffered the most casualties. Also called Old World vultures, these creatures are the most common large vultures in Africa. White-backed vultures feed on the carcasses of large dead animals, and they tend to gorge themselves so much on food that they can no longer fly. When this happens, they rest with their wings spread and backs facing the sun.Some of the main threats to white-backed vultures are loss of habitat due to agriculture, illegal capture for trade, hunting for traditional medicines, drowning in farm reservoirs, electrocution from electricity pylons, and poisoning. TAG Vultures, Critically Endangered Species, Poaching Ads by Amazon ENDS IN Close In Botswana, over 500 vultures considered critically endangered were found dead in one of the country’s protected wildlife management areas (WMA). The creatures evidently died after consuming the carcasses of three elephants believed to be poisoned by poachers.Mass Animal DeathOver 500 vultures and two tawny eagles are dead after consuming three dead elephants believed to have been poisoned by poachers. In a statement, the government said that incident happened in a protected WMA and denounced the poisoning that led to these deaths, calling it “dangerous and harmful to the environment.”In total, 537 vultures died, including 468 white-backed vultures, 10 cape vultures, 14 lappet-faced vultures, 17 white-headed vultures, and 28 hooded vultures. Unfortunately, all of the mentioned species are considered critically endangered in the International Union For Conservation of Nature Red List. Ads by Amazon AllVideo On Demand: Rent or BuyClothing & AccessoriesMajor AppliancesArts, Crafts & SewingAutomotiveBaby & NurseryBeauty & GroomingBooks & TextbooksCollectible CoinsCamera & PhotoCell Phones & AccessoriesClassical MusicComputers, Tablets & ComponentsBlu-Ray & DVDElectronic Components & Home AudioEntertainment CollectiblesVideo GamesOther Gift Card BrandsGrocery & Gourmet FoodPatio, Lawn & GardenHealth & HouseholdBusiness & Industrial SuppliesJewelryKindle StoreKitchen & DiningMagazinesMiscellaneousDigital MusicCDs & VinylMusical InstrumentsOffice & School SuppliesPet Food & SuppliesPatio, Lawn & GardenShoes, Handbags, Wallets, SunglassesSoftwareSports CollectiblesSports & FitnessHome ImprovementToys & GamesVHSVideo GamesWatches ⓒ 2018 All rights reserved. Do not reproduce without permission.last_img read more

These LGBTI people stripped naked to celebrate their extraordinary bodies

first_imgYou might feel too fat or too thin, too strong or too weak, and your eyes will go to the places perceived as ‘problems’.We asked 22 LGBTI people to strip naked, emotionally and physically, and talk about how they feel about their bodies.For some it was terrifying, but every person walked away feeling a little bit more empowered.LGBTI people strip off to show off their bodiesGeorgia‘I think a lot of people just worried about themselves, and loved themselves, it might be a little bit of a better world.’Mufseen‘I wanted to take part in this project because growing up I didn’t have many role models to look up to in the gay community. A lot of stuff in gay magazines or gay media is always white men, muscly bodies, and I’m none of those.’AdrianMalik‘I don’t think there’s a real body. Each person is built in a different shape and size. I think, we as a society, now need to stop focusing on how people are built.’AnthonyKristopher‘For me confidence is the biggest thing and I think no matter what size or shape you are, that’s what makes someone sexy to me. I think that’s what a lot of people overlook.’Ben MJames‘We’ve been programmed to think if you’re trans you need to want to alter yourself and that you’re only valid and you’re only allowed to exist and be appreciated if you alter yourself. Actually sometimes you don’t need to.’Roy‘After I see a bit of candy in front of me, somebody who I think is really beautiful on the outside, I just wonder if that beauty extends on the inside.’Ben WJack Arthur‘Day to day, we are all humans with different lives and with different journeys. It sounds so corny but we have to enjoy ourselves.’Corry How I learned to feel better naked in just one monthGay dating apps’ no fats, no femmes culture means I get no f**ksGay Bermuda tourism CEO: LGBTI boycott ‘counter-intuitive’ after marriage equality reversalRead the full article on Gaystarnews:  : eTN Chatroom for Readers (join us) This is why these LGBTI people got naked Share this:TwitterFacebookLike this:Like Loading… ‘To get comfortable with my body, I just decided that I was going to be comfortable. It sounds dumb, but I stood in front of the mirror every day and looked at myself until I liked it.’Liz‘My Adam’s apple is pretty a bit more pronounced than most women’s. But not wanting to be in that kind of all women’s bracket, there’s always a little bit of conflict there.’MattStefanos‘I’m not the hottest person in the world. A guy like me gets a lot of compliments and a lot of positive feedback, it doesn’t mean that this positive feedback is what I believe about myself.’Michael‘We see other people that look that kind of similar to ourselves, and think they look great. And we’re fine with that. But we don’t feel the same way about ourselves.’Riccardo‘I had this accident almost three years ago where I was basically crushed by a lorry and my pelvis got fractured. It’s thanks to that I came out to my family, I decided to come out to my family because there was a point where I have died…‘And yeah, and now I have these scars and sometimes when I’m at the gym I think they’re going to see my scars if I do this exercise, but two seconds later, I think OK, it’s not something I have to be ashamed of because that’s just the result of a surgery and I’m alive to show them and I’m not really as ashamed of them as, yeah, that’s what I think.’Jack‘From past relationships, I’ve had a lot of bad experiences where i got a lot of verbal abuse from it and they would pick out small things about my body that they didn’t like… I think they would just call me a lot of names, like marshmallow.‘It’s annoying that something like this just keeps sticking in your head.’Leonie‘It breaks my heart every day to see young people on social media posting about how they need to lose weight and how they need to tone up and how they need to look better.‘I find that society has gotten to a point where that’s not healthy anymore.’MohamedPablo‘Two years ago I was in an abusive relationship and it left with me with very low self-esteem. It’s taken me a long time to build my confidence back up again.’Simon Got a news tip? Want to share your story? Email us . GAYSTARNEWS- Bodies come in all shapes and sizes. But still, looking at your body naked in the mirror can be one of the most scariest things in the world.last_img read more

MNEK drops single off his debut album promises a black gay pop

first_imgGAYSTARNEWS- Gay artist MNEK has revealed details from his new album and dropped a new mellow single. The R&B star took to Instagram to call out a commenter on his Tongue video, who stated that the clip was ‘so wrong’ and said ‘you can clearly see a demon is in control of this guy and is doing this gay thing so it can poison minds’.He responded: ‘I’ve been working in this industry for a long time and have earned the right to now perform in a way that exhibits the true me.’‘I’m aware it’s not something everyone is used to seeing but that’s exactly why I wanted to do it. loving another man is not a demonic act, especially not in a music video!’Read more from Gay Star News:MNEK blasts Azealia Banks: ‘She actively hates gay people’ eTN Chatroom for Readers (join us) MNEK | Photo: Tongue artwork MNEK demonstrates how to shut down a homophobic hater MNEK on being black and gay: ‘One minority is bad enough’ Got a news tip? Want to share your story? Email us . Share this:TwitterFacebookLike this:Like Loading… The 23-year-old Londoner will release Language on September 7, via Virgin EMI.He’s also given fans a taste of what to expect in Crazy World, the latest song to emerge from the record.MNEK promises a ‘black, gay, pop experience’The artist previously promised his debut album to be a ‘black, gay, pop experience’.‘This album is so special to me because it’s something I’ve put my heart and soul into writing and producing and singing,’ he said.‘I’ve waited for the day my debut album is released my entire life, so naturally, I’ve designed it to be listened to from start to finish,’ he added.MNEK has been in the music industry for 10 years but this is his first solo album. He boasts an incredible list of production and writing credits. Notably, he wrote and produced for icons such as Beyoncé, Madonna, and Kylie Minogue, to name but a few.He explained ‘every song flows into each other in a way that tells a sonic story. I’ve learned so much as a musician over the years and most importantly as a young man’.Listen to Crazy World:[embedded content]He shut down homophobic commentsIn March this year, he received widespread praise for the way he shut down a homophobic Instagram user. Read the full article on Gaystarnews:  : read more

Autopilot Was Engaged During Fatal Tesla Crash

first_imgMay 17, 2019 Growing a business sometimes requires thinking outside the box. Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global This story originally appeared on PCMag 2 min read Register Now » On March 1, a Tesla Model 3 crashed into a semitrailer in Delray Beach, Florida, which sheared off the vehicle’s roof and proved fatal for the driver. A preliminary report released by the National Transportation Safety Board (NTSB) yesterday confirms Autopilot was engaged when the crash occurred.As Reuters reports, the NTSB concluded in its report that Autopilot had been engaged by the driver roughly 10 seconds before the crash happened. However, the driver’s hands were not detected on the wheel for eight of those seconds leading up to the crash. It’s also key to point out that the Model 3 was traveling at 68mph on a highway with a 55mph speed limit.Tesla has pointed out that before this crash occurred the driver engaged Autopilot and then, “immediately removed his hands from the wheel. Autopilot had not been used at any other time during that drive.” This suggests that over the course of 10 seconds and while traveling at speed, the driver had engaged driver assistance but then chose to stop being in control of the car.For now, Autopilot is only advertised as an advanced driver-assistance system offering lane centering, automatic lane changing, adaptive cruise control, self-parking, and summoning from a garage. It requires “active driver supervision” as stated on Tesla’s website and does not make the vehicle autonomous, although a self-driving upgrade is promised eventually.The NTSB is tasked with putting forward safety recommendations, however, the National Highway Traffic Safety Administration (NHTSA) is also investigating the crash and intends to “share any findings upon conclusion of its investigation.” The NHTSA holds the power to recall vehicles if “a defect poses an unreasonable safety risk.” Ultimately the NHTSA needs to decide if Autopilot is defective in its current form.last_img read more